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Endocrine Abstracts

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ea0049gp189 | Pituitary & endocrine Tumours | ECE2017

Evaluation of pituitary toxicity after radiotherapy for cerebral chondrosarcomas in adult patients

Laroche Suzanne , Feuvret Loic , Beauchet Alain , Dendale Remi , Chanson Philippe , Bruckert Eric , Jublanc Christel

Pituitary dysfunction can be a consequence of cranial radiotherapy. It usually occurs years after the treatment. However little is known on risk factors for pituitary dysfunction. The object of this study was to evaluate radiation induced pituitary toxicity of proton beam therapy in a cohort of adult chondrosarcoma patients.The files of 113 patients were reviewed. Mean age at the beginning of radiotherapy was 43 years old (18–76). Mean dose delivere...
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ea0099oc5.5 | Oral Communications 5: Pituitary and Neuroendocrinology | Part I | ECE2024

B-RAF and MEK inhibitor argeted therapy in papillary craniopharyngiomas: results from the French national multicenter study

De Alcubierre Dario , Gkasdaris Grigorios , Briet Claire , Almairac Fabien , Boetto Julien , Mouly Celine , Larrieu-Ciron Delphine , Joncour Anthony , Mordrel Margaux , Vasiljevic Alexandre , Villa Chiara , Sergeant Camille , Ducray Francois , Feuvret Loic , Baussart Bertrand , Raverot Gerald , Jouanneau Emmanuel

Background: Papillary craniopharyngiomas (PCPs) are driven by V600E BRAF mutations in 95% of cases. Recently, combined anti-BRAF/MEK targeted therapy (TT) has emerged as a potential treatment in aggressive PCPs. However, standardized data on large cohorts are still lacking. Our study aimed to assess the real-life efficacy and safety of TT in patients with PCPs.Methods: This was a retrospective national multicenter study involving patients with V600E BRAF...
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ea0099p501 | Endocrine-Related Cancer | ECE2024

Clinical features and outcome in patients with functional head and neck paragangliomas: French national cohort and literature review

Pinigina Iuliia , Ceruse Philippe , Herman Philippe , Catherine Cardot , Haissaguerre Magalie , Cornu Erika , Amar Laurence , Batisse-Lignier Marie , Chardon Laurence , Barraud Sara , Feuvret Loic , Janier Marc , Helene Lasolle , Borson-Chazot Francoise , Juliette Abeillon

Objectives: Management of functional head and neck paragangliomas (HNPGLf) presents a substantial challenge due to their rarity, the lack of standardized treatment protocols, their complex neurovascular anatomical location, and the cardiovascular risks associated with catecholamine (CA) hypersecretion. This study aimed to describe the clinical characteristics of HNPGLf and their treatment outcomes.Methods: We retrospectively analyzed a cohort of HNPGLf p...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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